The Admixture Model in Linkage Analysis

Jie Peng and D. Siegmund

Department of Statistics, Stanford University, Stanford, CA 94305

Abstract:

We study an appropriate version of the score statistic to test the hypothesis of no linkage in a sample of phase known meioses and show that accurate approximations to the genome wide significance level can be obtained by using a large deviation approximation to evaluate Rice¡¯s formula for the expected number of upcrossings of a smooth random process.

Keywords: heterogeneous traits, lack of identifiability, interval mapping, Rice-Davies approximation, large deviation theory